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An individual who has been receiving prednisone for six months and has an order to discontinue the medication today. You question the nurse about this because discontinuation may

  1. Cause an allergic reaction

  2. Cause dizziness

  3. Cause drowsiness

  4. Cause adrenal insufficiency

The correct answer is: Cause adrenal insufficiency

When a person has been taking prednisone for an extended period, their body can become dependent on the medication to regulate its response to inflammation, suppress the immune system, or manage stress. Suddenly stopping the medication can lead to adrenal insufficiency, where the body's adrenal glands do not produce enough cortisol. This can result in symptoms such as weakness, fatigue, weight loss, low blood pressure, and abdominal pain. It's important to gradually taper off prednisone under medical supervision to allow the adrenal glands to resume their normal function gradually. This ensures that the individual's body can adapt to producing cortisol on its own again, minimizing the risk of adrenal insufficiency.